ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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E3 ubiquitin-protein ligase RAD18

Intramolecular
Cysteine 204 and cysteine 207 L
Cysteine 204 and cysteine 223
Cysteine 207 and cysteine 223 L
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RAD18 between cysteines 204 and 207.

Details

Redox score ?
85
PDB code
2mrf
Structure name
nmr structure of the ubiquitin-binding zinc finger (ubz) domain from human rad18
Structure deposition date
2014-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
8
% buried
0
Peptide accession
Q9NS91
Residue number A
204
Residue number B
207
Peptide name
E3 ubiquitin-protein ligase RAD18

Ligandability

Cysteine 204 of E3 ubiquitin-protein ligase RAD18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of E3 ubiquitin-protein ligase RAD18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RAD18 between cysteines 204 and 223.

Details

Redox score ?
81
PDB code
5vf0
Structure name
solution nmr structure of human rad18 (198-240) in complex with ubiquitin
Structure deposition date
2017-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
20
Peptide accession
Q9NS91
Residue number A
204
Residue number B
223
Peptide name
E3 ubiquitin-protein ligase RAD18

Ligandability

Cysteine 204 of E3 ubiquitin-protein ligase RAD18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of E3 ubiquitin-protein ligase RAD18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RAD18 between cysteines 207 and 223.

Details

Redox score ?
77
PDB code
5vf0
Structure name
solution nmr structure of human rad18 (198-240) in complex with ubiquitin
Structure deposition date
2017-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
6
Peptide accession
Q9NS91
Residue number A
207
Residue number B
223
Peptide name
E3 ubiquitin-protein ligase RAD18

Ligandability

Cysteine 207 of E3 ubiquitin-protein ligase RAD18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 223 of E3 ubiquitin-protein ligase RAD18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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