ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fibroblast growth factor 21

Intramolecular
Cysteine 103 and cysteine 121
Cysteine 31 and cysteine 43
A redox-regulated disulphide may form within Fibroblast growth factor 21 between cysteines 103 and 121 (75 and 93 respectively in this structure).

Details

Redox score ?
77
PDB code
6m6f
Structure name
solution structure of disulfide bond mutaion of the core domain of fibroblast growth factor 21 (fgf21)
Structure deposition date
2020-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NSA1
Residue number A
103
Residue number B
121
Peptide name
Fibroblast growth factor 21

Ligandability

Cysteine 103 of Fibroblast growth factor 21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Fibroblast growth factor 21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor 21 between cysteines 31 and 43.

Details

Redox score ?
nan
PDB code
6m6f
Structure name
solution structure of disulfide bond mutaion of the core domain of fibroblast growth factor 21 (fgf21)
Structure deposition date
2020-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NSA1
Residue number A
31
Residue number B
43
Peptide name
Fibroblast growth factor 21

Ligandability

Cysteine 31 of Fibroblast growth factor 21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Fibroblast growth factor 21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 31 in protein A could not be asigned to a Uniprot residue.
Cysteine 43 in protein B could not be asigned to a Uniprot residue.
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