ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Phenylalanine--tRNA ligase beta subunit

Intramolecular
Cysteine 151 and cysteine 255
Cysteine 498 and cysteine 578
A redox-regulated disulphide may form within Phenylalanine--tRNA ligase beta subunit between cysteines 151 and 255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3l4g
Structure name
crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase
Structure deposition date
2009-12-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NSD9
Residue number A
151
Residue number B
255
Peptide name
Phenylalanine--tRNA ligase beta subunit

Ligandability

Cysteine 151 of Phenylalanine--tRNA ligase beta subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Phenylalanine--tRNA ligase beta subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phenylalanine--tRNA ligase beta subunit between cysteines 498 and 578. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
3l4g
Structure name
crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase
Structure deposition date
2009-12-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
97
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NSD9
Residue number A
498
Residue number B
578
Peptide name
Phenylalanine--tRNA ligase beta subunit

Ligandability

Cysteine 498 of Phenylalanine--tRNA ligase beta subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Phenylalanine--tRNA ligase beta subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: