a tool for identifying drug-targetable redox-active disulphides

SAM domain-containing protein SAMSN-1

Intramolecular

Cysteine 165 and cysteine 196

A redox-regulated disulphide may form within SAM domain-containing protein SAMSN-1 between cysteines 165 and 196 (28 and 59 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

53

PDB code

Structure name

nmr structure of the hacs1 sh3 domain

Structure deposition date

2019-11-15

Thiol separation (Å)

8

Half-sphere exposure sum ?

43

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

165

Residue number B

196

Peptide name

SAM domain-containing protein SAMSN-1

Ligandability

Cysteine 165 of SAM domain-containing protein SAMSN-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of SAM domain-containing protein SAMSN-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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