ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Three-prime repair exonuclease 1

Intramolecular
Cysteine 120 and cysteine 152
Cysteine 35 and cysteine 70
Cysteine 119 and cysteine 120
Cysteine 120 and cysteine 208
A redox-regulated disulphide may form within Three-prime repair exonuclease 1 between cysteines 120 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7tqq
Structure name
structure of human trex1-dna complex
Structure deposition date
2022-01-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
90
Peptide accession
Q9NSU2
Residue number A
120
Residue number B
152
Peptide name
Three-prime repair exonuclease 1

Ligandability

Cysteine 120 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Three-prime repair exonuclease 1 between cysteines 35 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6w10
Structure name
structure of mouse trex1 with e198k disease-associated mutation
Structure deposition date
2020-03-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q91XB0
Residue number A
35
Residue number B
70
Peptide name
Three-prime repair exonuclease 1

Ligandability

Cysteine 35 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Three-prime repair exonuclease 1 between cysteines 119 and 120. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
3mxi
Structure name
trex1 3' exonuclease d18n familial chilblain lupus mutant
Structure deposition date
2010-05-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
94
Peptide accession
Q91XB0
Residue number A
119
Residue number B
120
Peptide name
Three-prime repair exonuclease 1

Ligandability

Cysteine 119 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Three-prime repair exonuclease 1 between cysteines 120 and 208. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7tqq
Structure name
structure of human trex1-dna complex
Structure deposition date
2022-01-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NSU2
Residue number A
120
Residue number B
208
Peptide name
Three-prime repair exonuclease 1

Ligandability

Cysteine 120 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Three-prime repair exonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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