ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transmembrane protein 106B

Intermolecular
Cysteine 253 and cysteine 253
Cysteine 214 and cysteine 253
Cysteine 214 and cysteine 214
A redox-regulated disulphide may form between two units of Transmembrane protein 106B at cysteines 253 and 253.

Details

Redox score ?
71
PDB code
7saq
Structure name
cryo-em structure of tmem106b fibrils extracted from a ftld-tdp patient, polymorph 1
Structure deposition date
2021-09-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Transmembrane protein 106B
Peptide B name
Transmembrane protein 106B
Peptide A accession
Q9NUM4
Peptide B accession
Q9NUM4
Peptide A residue number
253
Peptide B residue number
253

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Transmembrane protein 106B at cysteines 214 and 253.

Details

Redox score ?
69
PDB code
7qwm
Structure name
tmem106b filaments with fold iii from multiple system atrophy (case 17)
Structure deposition date
2022-01-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide A name
Transmembrane protein 106B
Peptide B name
Transmembrane protein 106B
Peptide A accession
Q9NUM4
Peptide B accession
Q9NUM4
Peptide A residue number
214
Peptide B residue number
253

Ligandability

Cysteine 214 of Transmembrane protein 106B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 253 of Transmembrane protein 106B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Transmembrane protein 106B at cysteines 214 and 214. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7u13
Structure name
tmem106b(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with tdp-43 pathology (ftld-tdp) type a (case 4)
Structure deposition date
2022-02-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
Transmembrane protein 106B
Peptide B name
Transmembrane protein 106B
Peptide A accession
Q9NUM4
Peptide B accession
Q9NUM4
Peptide A residue number
214
Peptide B residue number
214

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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