ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TBC1 domain family member 23

Intramolecular
Cysteine 596 and cysteine 619
Cysteine 317 and cysteine 399
Cysteine 207 and cysteine 209
Cysteine 343 and cysteine 399
A redox-regulated disulphide may form within TBC1 domain family member 23 between cysteines 596 and 619 (37 and 60 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6jm5
Structure name
crystal structure of tbc1d23 c terminal domain
Structure deposition date
2019-03-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
81
Peptide accession
Q9NUY8
Residue number A
596
Residue number B
619
Peptide name
TBC1 domain family member 23

Ligandability

Cysteine 596 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 619 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TBC1 domain family member 23 between cysteines 317 and 399. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6jl7
Structure name
crystal structure of tbc1d23 n terminal domain
Structure deposition date
2019-03-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NUY8
Residue number A
317
Residue number B
399
Peptide name
TBC1 domain family member 23

Ligandability

Cysteine 317 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 399 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TBC1 domain family member 23 between cysteines 207 and 209. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6jl7
Structure name
crystal structure of tbc1d23 n terminal domain
Structure deposition date
2019-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
70
Peptide accession
Q9NUY8
Residue number A
207
Residue number B
209
Peptide name
TBC1 domain family member 23

Ligandability

Cysteine 207 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TBC1 domain family member 23 between cysteines 343 and 399. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6jl7
Structure name
crystal structure of tbc1d23 n terminal domain
Structure deposition date
2019-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NUY8
Residue number A
343
Residue number B
399
Peptide name
TBC1 domain family member 23

Ligandability

Cysteine 343 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 399 of TBC1 domain family member 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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