ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Integrator complex subunit 9

Intermolecular
Cysteine 637 and cysteine 513 of Integrator complex subunit 11
Intramolecular
Cysteine 282 and cysteine 311
Cysteine 14 and cysteine 28
Cysteine 14 and cysteine 84
Cysteine 282 and cysteine 446
Cysteine 14 and cysteine 106
Cysteine 5 and cysteine 471
A redox-regulated disulphide may form between cysteine 637 of Integrator complex subunit 9 and cysteine 513 of Integrator complex subunit 11. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
5v8w
Structure name
crystal structure of human integrator ints9-ints11 ctd complex
Structure deposition date
2017-03-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
82
Peptide A name
Integrator complex subunit 9
Peptide B name
Integrator complex subunit 11
Peptide A accession
Q9NV88
Peptide B accession
Q5TA45
Peptide A residue number
637
Peptide B residue number
513

Ligandability

Cysteine 637 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 513 of Integrator complex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 9 between cysteines 282 and 311. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
36
Peptide accession
Q9NV88
Residue number A
282
Residue number B
311
Peptide name
Integrator complex subunit 9

Ligandability

Cysteine 282 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 311 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 9 between cysteines 14 and 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7bfq
Structure name
structure of the integrator cleavage module with extended ints4 and rigid body docked ints9/11 ctd
Structure deposition date
2021-01-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NV88
Residue number A
14
Residue number B
28
Peptide name
Integrator complex subunit 9

Ligandability

Cysteine 14 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 28 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 9 between cysteines 14 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
88
Peptide accession
Q9NV88
Residue number A
14
Residue number B
84
Peptide name
Integrator complex subunit 9

Ligandability

Cysteine 14 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 9 between cysteines 282 and 446. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7bfp
Structure name
structure of the integrator cleavage module with ints4/9/11
Structure deposition date
2021-01-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
56
Peptide accession
Q9NV88
Residue number A
282
Residue number B
446
Peptide name
Integrator complex subunit 9

Ligandability

Cysteine 282 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 446 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 9 between cysteines 14 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7bfp
Structure name
structure of the integrator cleavage module with ints4/9/11
Structure deposition date
2021-01-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NV88
Residue number A
14
Residue number B
106
Peptide name
Integrator complex subunit 9

Ligandability

Cysteine 14 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 9 between cysteines 5 and 471. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7bfq
Structure name
structure of the integrator cleavage module with extended ints4 and rigid body docked ints9/11 ctd
Structure deposition date
2021-01-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
89
Peptide accession
Q9NV88
Residue number A
5
Residue number B
471
Peptide name
Integrator complex subunit 9

Ligandability

Cysteine 5 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Integrator complex subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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