Mediator of RNA polymerase II transcription subunit 17

Intermolecular

Cysteine 649 and cysteine 93 of Mediator of RNA polymerase II transcription subunit 28 L

Intramolecular

A redox-regulated disulphide may form between cysteine 649 of Mediator of RNA polymerase II transcription subunit 17 and cysteine 93 of Mediator of RNA polymerase II transcription subunit 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7emf

Structure name

human mediator (deletion of med1-idr) in a tail-extended conformation

Structure deposition date

2021-04-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Mediator of RNA polymerase II transcription subunit 17

Peptide B name

Mediator of RNA polymerase II transcription subunit 28

Peptide A accession

Q9NVC6

Peptide B accession

Q9H204

Peptide A residue number

649

Peptide B residue number

Ligandability

Cysteine 649 of Mediator of RNA polymerase II transcription subunit 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Mediator of RNA polymerase II transcription subunit 28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 17 between cysteines 302 and 344. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?