ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Exonuclease 3'-5' domain-containing protein 2

Intramolecular
Cysteine 168 and cysteine 186
Cysteine 109 and cysteine 186
Cysteine 109 and cysteine 168
A redox-regulated disulphide may form within Exonuclease 3'-5' domain-containing protein 2 between cysteines 168 and 186.

Details

Redox score ?
72
PDB code
6k1e
Structure name
crystal structure of exd2 exonuclease domain soaked in mg and gmp
Structure deposition date
2019-05-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
74
Peptide accession
Q9NVH0
Residue number A
168
Residue number B
186
Peptide name
Exonuclease 3'-5' domain-containing protein 2

Ligandability

Cysteine 168 of Exonuclease 3'-5' domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Exonuclease 3'-5' domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exonuclease 3'-5' domain-containing protein 2 between cysteines 109 and 186. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6k19
Structure name
crystal structure of exd2 exonuclease domain soaked in mg
Structure deposition date
2019-05-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
86
Peptide accession
Q9NVH0
Residue number A
109
Residue number B
186
Peptide name
Exonuclease 3'-5' domain-containing protein 2

Ligandability

Cysteine 109 of Exonuclease 3'-5' domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Exonuclease 3'-5' domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exonuclease 3'-5' domain-containing protein 2 between cysteines 109 and 168. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6k18
Structure name
crystal structure of exd2 exonuclease domain soaked in mn
Structure deposition date
2019-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
15
% buried
100
Peptide accession
Q9NVH0
Residue number A
109
Residue number B
168
Peptide name
Exonuclease 3'-5' domain-containing protein 2

Ligandability

Cysteine 109 of Exonuclease 3'-5' domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 168 of Exonuclease 3'-5' domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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