Integrator complex subunit 7
Intermolecular
Cysteine 722 of Integrator complex subunit 2 and cysteine 82
Cysteine 722 of Integrator complex subunit 2 and cysteine 42 L
Intramolecular
Cysteine 638 and cysteine 778
Cysteine 42 and cysteine 82 L
Cysteine 574 and cysteine 589
Cysteine 638 and cysteine 776
Cysteine 636 and cysteine 638
Cysteine 776 and cysteine 778
Cysteine 296 and cysteine 298
Cysteine 296 and cysteine 351
Cysteine 351 and cysteine 352
7cun B 722 G 82
A redox-regulated disulphide may form between cysteine 722 of Integrator complex subunit 2 and cysteine 82 of Integrator complex subunit 7. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
100
Peptide A name
Integrator complex subunit 2
Peptide B name
Integrator complex subunit 7
Peptide A accession
Q9H0H0
Peptide B accession
Q9NVH2
Peptide A residue number
722
Peptide B residue number
82
Ligandability
Cysteine 722 of Integrator complex subunit 2
Cysteine 82 of Integrator complex subunit 7
7cun B 722 G 42
A redox-regulated disulphide may form between cysteine 722 of Integrator complex subunit 2 and cysteine 42 of Integrator complex subunit 7. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
92
Peptide A name
Integrator complex subunit 2
Peptide B name
Integrator complex subunit 7
Peptide A accession
Q9H0H0
Peptide B accession
Q9NVH2
Peptide A residue number
722
Peptide B residue number
42
Ligandability
Cysteine 722 of Integrator complex subunit 2
Cysteine 42 of Integrator complex subunit 7
7cun G 638 G 778
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 638 and 778.
Details
Redox score ?
70
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
84
Peptide accession
Q9NVH2
Residue number A
638
Residue number B
778
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 638 of Integrator complex subunit 7
Cysteine 778 of Integrator complex subunit 7
7cun G 42 G 82
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 42 and 82.
Details
Redox score ?
65
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
92
Peptide accession
Q9NVH2
Residue number A
42
Residue number B
82
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 42 of Integrator complex subunit 7
Cysteine 82 of Integrator complex subunit 7
7cun G 574 G 589
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 574 and 589. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
43
Peptide accession
Q9NVH2
Residue number A
574
Residue number B
589
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 574 of Integrator complex subunit 7
Cysteine 589 of Integrator complex subunit 7
7cun G 638 G 776
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 638 and 776. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
72
Peptide accession
Q9NVH2
Residue number A
638
Residue number B
776
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 638 of Integrator complex subunit 7
Cysteine 776 of Integrator complex subunit 7
7cun G 636 G 638
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 636 and 638. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
7
% buried
80
Peptide accession
Q9NVH2
Residue number A
636
Residue number B
638
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 636 of Integrator complex subunit 7
Cysteine 638 of Integrator complex subunit 7
7cun G 776 G 778
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 776 and 778. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
65
Peptide accession
Q9NVH2
Residue number A
776
Residue number B
778
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 776 of Integrator complex subunit 7
Cysteine 778 of Integrator complex subunit 7
7cun G 296 G 298
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 296 and 298. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
74
Peptide accession
Q9NVH2
Residue number A
296
Residue number B
298
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 296 of Integrator complex subunit 7
Cysteine 298 of Integrator complex subunit 7
7cun G 296 G 351
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 296 and 351. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
82
Peptide accession
Q9NVH2
Residue number A
296
Residue number B
351
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 296 of Integrator complex subunit 7
Cysteine 351 of Integrator complex subunit 7
7cun G 351 G 352
A redox-regulated disulphide may form within Integrator complex subunit 7 between cysteines 351 and 352. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
92
Peptide accession
Q9NVH2
Residue number A
351
Residue number B
352
Peptide name
Integrator complex subunit 7
Ligandability
Cysteine 351 of Integrator complex subunit 7
Cysteine 352 of Integrator complex subunit 7
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