Protein arginine N-methyltransferase 7
Intramolecular
Cysteine 219 and cysteine 366
Cysteine 366 and cysteine 368
Cysteine 219 and cysteine 368
Cysteine 571 and cysteine 639
Cysteine 534 and cysteine 537
Cysteine 405 and cysteine 407
Cysteine 639 and cysteine 640
Cysteine 226 and cysteine 317
Cysteine 571 and cysteine 640
4c4a A 219 A 366
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 219 and 366.
Details
Redox score ?
78
PDB code
4c4a
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sah
Structure deposition date
2013-09-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
nan
Peptide accession
Q922X9
Residue number A
219
Residue number B
366
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 219 of Protein arginine N-methyltransferase 7
Cysteine 366 of Protein arginine N-methyltransferase 7
6ogn A 366 A 368
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 366 and 368.
Details
Redox score ?
76
PDB code
6ogn
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sgc8158 chemical probe
Structure deposition date
2019-04-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q922X9
Residue number A
366
Residue number B
368
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 366 of Protein arginine N-methyltransferase 7
Cysteine 368 of Protein arginine N-methyltransferase 7
6ogn A 219 A 368
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 219 and 368.
Details
Redox score ?
74
PDB code
6ogn
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sgc8158 chemical probe
Structure deposition date
2019-04-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q922X9
Residue number A
219
Residue number B
368
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 219 of Protein arginine N-methyltransferase 7
Cysteine 368 of Protein arginine N-methyltransferase 7
4c4a A 571 A 639
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 571 and 639.
Details
Redox score ?
74
PDB code
4c4a
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sah
Structure deposition date
2013-09-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
84
Peptide accession
Q922X9
Residue number A
571
Residue number B
639
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 571 of Protein arginine N-methyltransferase 7
Cysteine 639 of Protein arginine N-methyltransferase 7
4c4a A 534 A 537
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 534 and 537.
Details
Redox score ?
74
PDB code
4c4a
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sah
Structure deposition date
2013-09-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
72
Peptide accession
Q922X9
Residue number A
534
Residue number B
537
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 534 of Protein arginine N-methyltransferase 7
Cysteine 537 of Protein arginine N-methyltransferase 7
4c4a A 405 A 407
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 405 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4c4a
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sah
Structure deposition date
2013-09-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
90
Peptide accession
Q922X9
Residue number A
405
Residue number B
407
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 405 of Protein arginine N-methyltransferase 7
Cysteine 407 of Protein arginine N-methyltransferase 7
6ogn A 639 A 640
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 639 and 640. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6ogn
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sgc8158 chemical probe
Structure deposition date
2019-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q922X9
Residue number A
639
Residue number B
640
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 639 of Protein arginine N-methyltransferase 7
Cysteine 640 of Protein arginine N-methyltransferase 7
6ogn A 226 A 317
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 226 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6ogn
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sgc8158 chemical probe
Structure deposition date
2019-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q922X9
Residue number A
226
Residue number B
317
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 226 of Protein arginine N-methyltransferase 7
Cysteine 317 of Protein arginine N-methyltransferase 7
4c4a A 571 A 640
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 7 between cysteines 571 and 640. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
4c4a
Structure name
crystal structure of mouse protein arginine methyltransferase 7 in complex with sah
Structure deposition date
2013-09-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
54
Peptide accession
Q922X9
Residue number A
571
Residue number B
640
Peptide name
Protein arginine N-methyltransferase 7
Ligandability
Cysteine 571 of Protein arginine N-methyltransferase 7
Cysteine 640 of Protein arginine N-methyltransferase 7
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