ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Integrator complex subunit 13

Intermolecular
Cysteine 406 and cysteine 310 of Integrator complex subunit 14
Intramolecular
Cysteine 24 and cysteine 54 L
Cysteine 556 and cysteine 560
Cysteine 17 and cysteine 120
Cysteine 119 and cysteine 120
Cysteine 494 and cysteine 556
Cysteine 134 and cysteine 202
A redox-regulated disulphide may form between cysteine 406 of Integrator complex subunit 13 and cysteine 310 of Integrator complex subunit 14. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6sn1
Structure name
crystal structure of the human ints13-ints14 complex
Structure deposition date
2019-08-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
80
Peptide A name
Integrator complex subunit 13
Peptide B name
Integrator complex subunit 14
Peptide A accession
Q9NVM9
Peptide B accession
Q96SY0
Peptide A residue number
406
Peptide B residue number
310

Ligandability

Cysteine 406 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Integrator complex subunit 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 13 between cysteines 24 and 54.

Details

Redox score ?
75
PDB code
6sn1
Structure name
crystal structure of the human ints13-ints14 complex
Structure deposition date
2019-08-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
6
% buried
85
Peptide accession
Q9NVM9
Residue number A
24
Residue number B
54
Peptide name
Integrator complex subunit 13

Ligandability

Cysteine 24 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 13 between cysteines 556 and 560.

Details

Redox score ?
72
PDB code
6sn1
Structure name
crystal structure of the human ints13-ints14 complex
Structure deposition date
2019-08-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
32
Peptide accession
Q9NVM9
Residue number A
556
Residue number B
560
Peptide name
Integrator complex subunit 13

Ligandability

Cysteine 556 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 560 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 13 between cysteines 17 and 120.

Details

Redox score ?
71
PDB code
6sn1
Structure name
crystal structure of the human ints13-ints14 complex
Structure deposition date
2019-08-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
30
Peptide accession
Q9NVM9
Residue number A
17
Residue number B
120
Peptide name
Integrator complex subunit 13

Ligandability

Cysteine 17 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 13 between cysteines 119 and 120. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6sn1
Structure name
crystal structure of the human ints13-ints14 complex
Structure deposition date
2019-08-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
4
Peptide accession
Q9NVM9
Residue number A
119
Residue number B
120
Peptide name
Integrator complex subunit 13

Ligandability

Cysteine 119 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 13 between cysteines 494 and 556. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6sn1
Structure name
crystal structure of the human ints13-ints14 complex
Structure deposition date
2019-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
58
Peptide accession
Q9NVM9
Residue number A
494
Residue number B
556
Peptide name
Integrator complex subunit 13

Ligandability

Cysteine 494 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 556 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 13 between cysteines 134 and 202. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6sn1
Structure name
crystal structure of the human ints13-ints14 complex
Structure deposition date
2019-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
84
Peptide accession
Q9NVM9
Residue number A
134
Residue number B
202
Peptide name
Integrator complex subunit 13

Ligandability

Cysteine 134 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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