a tool for identifying drug-targetable redox-active disulphides

Fas apoptotic inhibitory molecule 1

Intramolecular

Cysteine 122 and cysteine 149

A redox-regulated disulphide may form within Fas apoptotic inhibitory molecule 1 between cysteines 122 and 149 (32 and 59 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

50

PDB code

Structure name

solution structure of ctd

Structure deposition date

2010-03-30

Thiol separation (Å)

8

Half-sphere exposure sum ?

57

Minimum pK_a ?

11

% buried

42

Peptide accession

Residue number A

122

Residue number B

149

Peptide name

Fas apoptotic inhibitory molecule 1

Ligandability

Cysteine 122 of Fas apoptotic inhibitory molecule 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Fas apoptotic inhibitory molecule 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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