ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Poly(A) RNA polymerase, mitochondrial

Intermolecular
Cysteine 291 and cysteine 291
Intramolecular
Cysteine 299 and cysteine 324
Cysteine 291 and cysteine 299
Cysteine 211 and cysteine 324
A redox-regulated disulphide may form between two units of Poly(A) RNA polymerase, mitochondrial at cysteines 291 and 291. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3pq1
Structure name
crystal structure of human mitochondrial poly(a) polymerase (papd1)
Structure deposition date
2010-11-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
100
Peptide A name
Poly(A) RNA polymerase, mitochondrial
Peptide B name
Poly(A) RNA polymerase, mitochondrial
Peptide A accession
Q9NVV4
Peptide B accession
Q9NVV4
Peptide A residue number
291
Peptide B residue number
291

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly(A) RNA polymerase, mitochondrial between cysteines 299 and 324. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3pq1
Structure name
crystal structure of human mitochondrial poly(a) polymerase (papd1)
Structure deposition date
2010-11-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
92
Peptide accession
Q9NVV4
Residue number A
299
Residue number B
324
Peptide name
Poly(A) RNA polymerase, mitochondrial

Ligandability

Cysteine 299 of Poly(A) RNA polymerase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Poly(A) RNA polymerase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly(A) RNA polymerase, mitochondrial between cysteines 291 and 299. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3pq1
Structure name
crystal structure of human mitochondrial poly(a) polymerase (papd1)
Structure deposition date
2010-11-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
97
Peptide accession
Q9NVV4
Residue number A
291
Residue number B
299
Peptide name
Poly(A) RNA polymerase, mitochondrial

Ligandability

Cysteine 291 of Poly(A) RNA polymerase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Poly(A) RNA polymerase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly(A) RNA polymerase, mitochondrial between cysteines 211 and 324. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3pq1
Structure name
crystal structure of human mitochondrial poly(a) polymerase (papd1)
Structure deposition date
2010-11-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
91
Peptide accession
Q9NVV4
Residue number A
211
Residue number B
324
Peptide name
Poly(A) RNA polymerase, mitochondrial

Ligandability

Cysteine 211 of Poly(A) RNA polymerase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Poly(A) RNA polymerase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: