ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

THAP domain-containing protein 1

Intramolecular
Cysteine 5 and cysteine 10
Cysteine 5 and cysteine 54
Cysteine 10 and cysteine 54
A redox-regulated disulphide may form within THAP domain-containing protein 1 between cysteines 5 and 10.

Details

Redox score ?
92
PDB code
2ko0
Structure name
solution structure of the thap zinc finger of thap1 in complex with its dna target
Structure deposition date
2009-09-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
1
% buried
74
Peptide accession
Q9NVV9
Residue number A
5
Residue number B
10
Peptide name
THAP domain-containing protein 1

Ligandability

Cysteine 5 of THAP domain-containing protein 1

Cysteine 10 of THAP domain-containing protein 1

A redox-regulated disulphide may form within THAP domain-containing protein 1 between cysteines 5 and 54.

Details

Redox score ?
90
PDB code
2ko0
Structure name
solution structure of the thap zinc finger of thap1 in complex with its dna target
Structure deposition date
2009-09-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
1
% buried
81
Peptide accession
Q9NVV9
Residue number A
5
Residue number B
54
Peptide name
THAP domain-containing protein 1

Ligandability

Cysteine 5 of THAP domain-containing protein 1

Cysteine 54 of THAP domain-containing protein 1

A redox-regulated disulphide may form within THAP domain-containing protein 1 between cysteines 10 and 54.

Details

Redox score ?
67
PDB code
2l1g
Structure name
rdc refined solution structure of the thap zinc finger of thap1 in complex with its 16bp rrm1 dna target
Structure deposition date
2010-07-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
12
% buried
62
Peptide accession
Q9NVV9
Residue number A
10
Residue number B
54
Peptide name
THAP domain-containing protein 1

Ligandability

Cysteine 10 of THAP domain-containing protein 1

Cysteine 54 of THAP domain-containing protein 1

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