ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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E3 ubiquitin-protein ligase RLIM

Intramolecular
Cysteine 607 and cysteine 610
Cysteine 588 and cysteine 610
Cysteine 588 and cysteine 607
Cysteine 570 and cysteine 573
Cysteine 573 and cysteine 596
Cysteine 570 and cysteine 596
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RLIM between cysteines 607 and 610.

Details

Redox score ?
82
PDB code
6w9a
Structure name
rnf12 ring domain in complex with ube2e2
Structure deposition date
2020-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
22
Peptide accession
Q9NVW2
Residue number A
607
Residue number B
610
Peptide name
E3 ubiquitin-protein ligase RLIM

Ligandability

Cysteine 607 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 610 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RLIM between cysteines 588 and 610.

Details

Redox score ?
79
PDB code
6w9a
Structure name
rnf12 ring domain in complex with ube2e2
Structure deposition date
2020-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
8
% buried
8
Peptide accession
Q9NVW2
Residue number A
588
Residue number B
610
Peptide name
E3 ubiquitin-protein ligase RLIM

Ligandability

Cysteine 588 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 610 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RLIM between cysteines 588 and 607.

Details

Redox score ?
78
PDB code
6w7z
Structure name
rnf12 ring domain in complex with ube2d2
Structure deposition date
2020-03-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
32
Peptide accession
Q9NVW2
Residue number A
588
Residue number B
607
Peptide name
E3 ubiquitin-protein ligase RLIM

Ligandability

Cysteine 588 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 607 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RLIM between cysteines 570 and 573.

Details

Redox score ?
72
PDB code
6w9d
Structure name
rnf12 ring domain in complex with a ube2d2~ub conjugate
Structure deposition date
2020-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9NVW2
Residue number A
570
Residue number B
573
Peptide name
E3 ubiquitin-protein ligase RLIM

Ligandability

Cysteine 570 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 573 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RLIM between cysteines 573 and 596.

Details

Redox score ?
71
PDB code
6w7z
Structure name
rnf12 ring domain in complex with ube2d2
Structure deposition date
2020-03-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
66
Peptide accession
Q9NVW2
Residue number A
573
Residue number B
596
Peptide name
E3 ubiquitin-protein ligase RLIM

Ligandability

Cysteine 573 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 596 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RLIM between cysteines 570 and 596. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6w9d
Structure name
rnf12 ring domain in complex with a ube2d2~ub conjugate
Structure deposition date
2020-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
19
% buried
nan
Peptide accession
Q9NVW2
Residue number A
570
Residue number B
596
Peptide name
E3 ubiquitin-protein ligase RLIM

Ligandability

Cysteine 570 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 596 of E3 ubiquitin-protein ligase RLIM

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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