a tool for identifying drug-targetable redox-active disulphides

Kelch repeat and BTB domain-containing protein 4

Intramolecular

Cysteine 147 and cysteine 169

A redox-regulated disulphide may form within Kelch repeat and BTB domain-containing protein 4 between cysteines 147 and 169 (163 and 185 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

59

PDB code

Structure name

solution structure of the back domain of kelch repeat and btb domain- containing protein 4

Structure deposition date

2007-03-30

Thiol separation (Å)

6

Half-sphere exposure sum ?

65

Minimum pK_a ?

10

% buried

34

Peptide accession

Residue number A

147

Residue number B

169

Peptide name

Kelch repeat and BTB domain-containing protein 4

Ligandability

Cysteine 147 of Kelch repeat and BTB domain-containing protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Kelch repeat and BTB domain-containing protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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