DNA-directed RNA polymerase III subunit RPC2
Intermolecular
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5 and cysteine 924
Cysteine 924 and cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 19 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 1110
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 1092
Cysteine 919 and cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 924 and cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 924 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 527 and cysteine 354 of DNA-directed RNA polymerase III subunit RPC4
Cysteine 919 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Intramolecular
Cysteine 1080 and cysteine 1095
More...Cysteine 1080 and cysteine 1083
Cysteine 1083 and cysteine 1092
Cysteine 1092 and cysteine 1095
Cysteine 1083 and cysteine 1095
Cysteine 1080 and cysteine 1099
Cysteine 1080 and cysteine 1092
Cysteine 1095 and cysteine 1099
Cysteine 480 and cysteine 687
Cysteine 668 and cysteine 687
Cysteine 480 and cysteine 668
Cysteine 332 and cysteine 527
Cysteine 777 and cysteine 815
Cysteine 1092 and cysteine 1099
Cysteine 102 and cysteine 145
Cysteine 919 and cysteine 924
Cysteine 769 and cysteine 907
7ast B 10 M 924
A redox-regulated disulphide may form between cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5 and cysteine 924 of DNA-directed RNA polymerase III subunit RPC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
6
% buried
100
Peptide A name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide B name
DNA-directed RNA polymerase III subunit RPC2
Peptide A accession
P62875
Peptide B accession
Q9NW08
Peptide A residue number
10
Peptide B residue number
924
Ligandability
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
7du2 B 924 J 45
A redox-regulated disulphide may form between cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
3
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
924
Peptide B residue number
45
Ligandability
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 45 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7ast N 19 M 1110
A redox-regulated disulphide may form between cysteine 19 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 1110 of DNA-directed RNA polymerase III subunit RPC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
80
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC2
Peptide A accession
O14802
Peptide B accession
Q9NW08
Peptide A residue number
19
Peptide B residue number
1110
Ligandability
Cysteine 19 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 1110 of DNA-directed RNA polymerase III subunit RPC2
7ast N 72 M 1092
A redox-regulated disulphide may form between cysteine 72 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
72
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC2
Peptide A accession
O14802
Peptide B accession
Q9NW08
Peptide A residue number
72
Peptide B residue number
1092
Ligandability
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2
7dn3 B 919 J 10
A redox-regulated disulphide may form between cysteine 919 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
11
% buried
nan
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
919
Peptide B residue number
10
Ligandability
Cysteine 919 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 10 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7fjj B 924 J 7
A redox-regulated disulphide may form between cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
nan
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
924
Peptide B residue number
7
Ligandability
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 7 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7aea B 924 J 44
A redox-regulated disulphide may form between cysteine 924 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
924
Peptide B residue number
44
Ligandability
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7a6h B 527 N 354
A redox-regulated disulphide may form between cysteine 527 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 354 of DNA-directed RNA polymerase III subunit RPC4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerase III subunit RPC4
Peptide A accession
Q9NW08
Peptide B accession
P05423
Peptide A residue number
527
Peptide B residue number
354
Ligandability
Cysteine 527 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 354 of DNA-directed RNA polymerase III subunit RPC4
7ae3 B 919 J 44
A redox-regulated disulphide may form between cysteine 919 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
22
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
14
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC2
Peptide B name
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Peptide A accession
Q9NW08
Peptide B accession
P62875
Peptide A residue number
919
Peptide B residue number
44
Ligandability
Cysteine 919 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 44 of DNA-directed RNA polymerases I, II, and III subunit RPABC5
7fjj B 1080 B 1095
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1080 and 1095.
Details
Redox score ?
79
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
42
Peptide accession
Q9NW08
Residue number A
1080
Residue number B
1095
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1080 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1095 of DNA-directed RNA polymerase III subunit RPC2
7fjj B 1080 B 1083
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1080 and 1083.
Details
Redox score ?
74
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
55
Peptide accession
Q9NW08
Residue number A
1080
Residue number B
1083
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1080 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1083 of DNA-directed RNA polymerase III subunit RPC2
7ae1 B 1083 B 1092
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1083 and 1092.
Details
Redox score ?
72
PDB code
7ae1
Structure name
cryo-em structure of human rna polymerase iii elongation complex 1
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
61
Peptide accession
Q9NW08
Residue number A
1083
Residue number B
1092
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1083 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2
7ae3 B 1092 B 1095
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1092 and 1095.
Details
Redox score ?
69
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
45
Peptide accession
Q9NW08
Residue number A
1092
Residue number B
1095
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1095 of DNA-directed RNA polymerase III subunit RPC2
7fji B 1083 B 1095
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1083 and 1095.
Details
Redox score ?
68
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
50
Peptide accession
Q9NW08
Residue number A
1083
Residue number B
1095
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1083 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1095 of DNA-directed RNA polymerase III subunit RPC2
7d58 B 1080 B 1099
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1080 and 1099. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7d58
Structure name
cryo-em structure of human rna polymerase iii in elongating state
Structure deposition date
2020-09-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
32
Peptide accession
Q9NW08
Residue number A
1080
Residue number B
1099
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1080 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1099 of DNA-directed RNA polymerase III subunit RPC2
7ast M 1080 M 1092
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1080 and 1092. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
50
Peptide accession
Q9NW08
Residue number A
1080
Residue number B
1092
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1080 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2
7ae3 B 1095 B 1099
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1095 and 1099. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
22
Peptide accession
Q9NW08
Residue number A
1095
Residue number B
1099
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1095 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1099 of DNA-directed RNA polymerase III subunit RPC2
7ast M 480 M 687
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 480 and 687. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NW08
Residue number A
480
Residue number B
687
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 480 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 687 of DNA-directed RNA polymerase III subunit RPC2
7d58 B 668 B 687
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 668 and 687. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7d58
Structure name
cryo-em structure of human rna polymerase iii in elongating state
Structure deposition date
2020-09-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NW08
Residue number A
668
Residue number B
687
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 668 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 687 of DNA-directed RNA polymerase III subunit RPC2
7dn3 B 480 B 668
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 480 and 668. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
11
% buried
100
Peptide accession
Q9NW08
Residue number A
480
Residue number B
668
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 480 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 668 of DNA-directed RNA polymerase III subunit RPC2
7du2 B 332 B 527
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 332 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NW08
Residue number A
332
Residue number B
527
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 332 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 527 of DNA-directed RNA polymerase III subunit RPC2
7dn3 B 777 B 815
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 777 and 815. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
94
Peptide accession
Q9NW08
Residue number A
777
Residue number B
815
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 777 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 815 of DNA-directed RNA polymerase III subunit RPC2
7a6h B 1092 B 1099
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 1092 and 1099. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
56
Peptide accession
Q9NW08
Residue number A
1092
Residue number B
1099
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 1099 of DNA-directed RNA polymerase III subunit RPC2
7dn3 B 102 B 145
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 102 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
97
Peptide accession
Q9NW08
Residue number A
102
Residue number B
145
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 102 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 145 of DNA-directed RNA polymerase III subunit RPC2
7ae1 B 919 B 924
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 919 and 924. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7ae1
Structure name
cryo-em structure of human rna polymerase iii elongation complex 1
Structure deposition date
2020-09-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
100
Peptide accession
Q9NW08
Residue number A
919
Residue number B
924
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 919 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 924 of DNA-directed RNA polymerase III subunit RPC2
7ast M 769 M 907
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC2 between cysteines 769 and 907. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
25
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NW08
Residue number A
769
Residue number B
907
Peptide name
DNA-directed RNA polymerase III subunit RPC2
Ligandability
Cysteine 769 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 907 of DNA-directed RNA polymerase III subunit RPC2
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