ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anoctamin-10

Intramolecular
Cysteine 323 and cysteine 325
Cysteine 513 and cysteine 571
A redox-regulated disulphide may form within Anoctamin-10 between cysteines 323 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5oc9
Structure name
crystal structure of human tmem16k / anoctamin 10
Structure deposition date
2017-06-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
36
Peptide accession
Q9NW15
Residue number A
323
Residue number B
325
Peptide name
Anoctamin-10

Ligandability

Cysteine 323 of Anoctamin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Anoctamin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anoctamin-10 between cysteines 513 and 571. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
5oc9
Structure name
crystal structure of human tmem16k / anoctamin 10
Structure deposition date
2017-06-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
92
Peptide accession
Q9NW15
Residue number A
513
Residue number B
571
Peptide name
Anoctamin-10

Ligandability

Cysteine 513 of Anoctamin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 571 of Anoctamin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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