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a tool for identifying drug-targetable redox-active disulphides

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Pre-mRNA-splicing factor RBM22

Intramolecular
Cysteine 173 and cysteine 179
Cysteine 27 and cysteine 84
Cysteine 27 and cysteine 81
Cysteine 165 and cysteine 173
Cysteine 165 and cysteine 179
Cysteine 48 and cysteine 74
Cysteine 45 and cysteine 71
Cysteine 71 and cysteine 74
Cysteine 48 and cysteine 71
Cysteine 45 and cysteine 48
More...
Cysteine 81 and cysteine 84
Cysteine 45 and cysteine 74
Cysteine 24 and cysteine 84
Cysteine 24 and cysteine 81
Cysteine 24 and cysteine 27
A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 173 and 179.

Details

Redox score ?
96
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
1
% buried
58
Peptide accession
Q9NW64
Residue number A
173
Residue number B
179
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 173 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 27 and 84.

Details

Redox score ?
88
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
2
% buried
nan
Peptide accession
Q9NW64
Residue number A
27
Residue number B
84
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 27 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 27 and 81.

Details

Redox score ?
84
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
2
% buried
100
Peptide accession
Q9NW64
Residue number A
27
Residue number B
81
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 27 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 165 and 173.

Details

Redox score ?
82
PDB code
6id0
Structure name
cryo-em structure of a human intron lariat spliceosome prior to prp43 loaded (ils1 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
67
Peptide accession
Q9NW64
Residue number A
165
Residue number B
173
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 165 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 165 and 179.

Details

Redox score ?
81
PDB code
6id1
Structure name
cryo-em structure of a human intron lariat spliceosome after prp43 loaded (ils2 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
82
Peptide accession
Q9NW64
Residue number A
165
Residue number B
179
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 165 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 48 and 74.

Details

Redox score ?
79
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
5
% buried
94
Peptide accession
Q9NW64
Residue number A
48
Residue number B
74
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 48 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 45 and 71.

Details

Redox score ?
78
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
nan
Peptide accession
Q9NW64
Residue number A
45
Residue number B
71
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 45 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 71 and 74.

Details

Redox score ?
77
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
79
Minimum pKa ?
6
% buried
98
Peptide accession
Q9NW64
Residue number A
71
Residue number B
74
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 71 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 48 and 71.

Details

Redox score ?
74
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
5
% buried
95
Peptide accession
Q9NW64
Residue number A
48
Residue number B
71
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 48 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 45 and 48.

Details

Redox score ?
66
PDB code
7w5a
Structure name
the cryo-em structure of human pre-c*-ii complex
Structure deposition date
2021-11-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
15
% buried
nan
Peptide accession
Q9NW64
Residue number A
45
Residue number B
48
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 45 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 81 and 84.

Details

Redox score ?
63
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9NW64
Residue number A
81
Residue number B
84
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 81 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 45 and 74.

Details

Redox score ?
61
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
16
% buried
nan
Peptide accession
Q9NW64
Residue number A
45
Residue number B
74
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 45 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 24 and 84.

Details

Redox score ?
60
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
14
% buried
100
Peptide accession
Q9NW64
Residue number A
24
Residue number B
84
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 24 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 24 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7w5a
Structure name
the cryo-em structure of human pre-c*-ii complex
Structure deposition date
2021-11-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NW64
Residue number A
24
Residue number B
81
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 24 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor RBM22 between cysteines 24 and 27. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6id0
Structure name
cryo-em structure of a human intron lariat spliceosome prior to prp43 loaded (ils1 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
23
% buried
nan
Peptide accession
Q9NW64
Residue number A
24
Residue number B
27
Peptide name
Pre-mRNA-splicing factor RBM22

Ligandability

Cysteine 24 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Pre-mRNA-splicing factor RBM22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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