ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Transmembrane protein 45A

Intramolecular
Cysteine 224 and cysteine 226
A redox-regulated disulphide may form within Transmembrane protein 45A between cysteines 224 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7oqz
Structure name
cryo-em structure of human tmem45a
Structure deposition date
2021-06-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
12
% buried
92
Peptide accession
Q9NWC5
Residue number A
224
Residue number B
226
Peptide name
Transmembrane protein 45A

Ligandability

Cysteine 224 of Transmembrane protein 45A

Cysteine 226 of Transmembrane protein 45A

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