ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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PIH1 domain-containing protein 1

Intramolecular
Cysteine 55 and cysteine 117
Cysteine 55 and cysteine 70
A redox-regulated disulphide may form within PIH1 domain-containing protein 1 between cysteines 55 and 117. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4psi
Structure name
pih1d1/phospho-tel2 complex
Structure deposition date
2014-03-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
89
Peptide accession
Q9NWS0
Residue number A
55
Residue number B
117
Peptide name
PIH1 domain-containing protein 1

Ligandability

Cysteine 55 of PIH1 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of PIH1 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PIH1 domain-containing protein 1 between cysteines 55 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4psi
Structure name
pih1d1/phospho-tel2 complex
Structure deposition date
2014-03-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
90
Peptide accession
Q9NWS0
Residue number A
55
Residue number B
70
Peptide name
PIH1 domain-containing protein 1

Ligandability

Cysteine 55 of PIH1 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of PIH1 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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