a tool for identifying drug-targetable redox-active disulphides

39S ribosomal protein L22, mitochondrial

Intramolecular

Cysteine 146 and cysteine 166

A redox-regulated disulphide may form within 39S ribosomal protein L22, mitochondrial between cysteines 146 and 166 (152 and 172 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

48

PDB code

Structure name

structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rrna

Structure deposition date

2017-08-08

Thiol separation (Å)

9

Half-sphere exposure sum ?

50

Minimum pK_a ?

9

% buried

96

Peptide accession

Residue number A

146

Residue number B

166

Peptide name

39S ribosomal protein L22, mitochondrial

Ligandability

Cysteine 146 of 39S ribosomal protein L22, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of 39S ribosomal protein L22, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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