Interleukin-1 receptor-associated kinase 4
6ti8 A 276 D 276
A redox-regulated disulphide may form between two units of Interleukin-1 receptor-associated kinase 4 at cysteines 276 and 276. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6ti8
Structure name
irak4 in complex with inhibitor
Structure deposition date
2019-11-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
80
Peptide A name
Interleukin-1 receptor-associated kinase 4
Peptide B name
Interleukin-1 receptor-associated kinase 4
Peptide A accession
Q9NWZ3
Peptide B accession
Q9NWZ3
Peptide A residue number
276
Peptide B residue number
276
Ligandability
3mop J 13 J 79
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 4 between cysteines 13 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
3mop
Structure name
the ternary death domain complex of myd88, irak4, and irak2
Structure deposition date
2010-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
71
Peptide accession
Q9NWZ3
Residue number A
13
Residue number B
79
Peptide name
Interleukin-1 receptor-associated kinase 4
Ligandability
Cysteine 13 of Interleukin-1 receptor-associated kinase 4
Cysteine 79 of Interleukin-1 receptor-associated kinase 4
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