ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

ADP-ribosylhydrolase ARH3

Intramolecular
Cysteine 35 and cysteine 343
Cysteine 283 and cysteine 287
A redox-regulated disulphide may form within ADP-ribosylhydrolase ARH3 between cysteines 35 and 343.

Details

Redox score ?
68
PDB code
7arw
Structure name
structure of human arh3 e41a bound to alpha-nad+ and magnesium
Structure deposition date
2020-10-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide accession
Q9NX46
Residue number A
35
Residue number B
343
Peptide name
ADP-ribosylhydrolase ARH3

Ligandability

Cysteine 35 of ADP-ribosylhydrolase ARH3

Cysteine 343 of ADP-ribosylhydrolase ARH3

A redox-regulated disulphide may form within ADP-ribosylhydrolase ARH3 between cysteines 283 and 287 (267 and 271 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2fp0
Structure name
human adp-ribosylhydrolase 3
Structure deposition date
2006-01-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NX46
Residue number A
283
Residue number B
287
Peptide name
ADP-ribosylhydrolase ARH3

Ligandability

Cysteine 283 of ADP-ribosylhydrolase ARH3

Cysteine 287 of ADP-ribosylhydrolase ARH3

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