Mediator of RNA polymerase II transcription subunit 29

Intramolecular

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 29 between cysteines 126 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7emf

Structure name

human mediator (deletion of med1-idr) in a tail-extended conformation

Structure deposition date

2021-04-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q9NX70

Residue number A

126

Residue number B

131

Peptide name

Mediator of RNA polymerase II transcription subunit 29

Ligandability

Cysteine 126 of Mediator of RNA polymerase II transcription subunit 29

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.