ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NAD-dependent protein deacylase sirtuin-5, mitochondrial

Intramolecular
Cysteine 166 and cysteine 212
Cysteine 166 and cysteine 207
Cysteine 166 and cysteine 169
Cysteine 207 and cysteine 212
Cysteine 169 and cysteine 207
Cysteine 169 and cysteine 212
Cysteine 242 and cysteine 245
A redox-regulated disulphide may form within NAD-dependent protein deacylase sirtuin-5, mitochondrial between cysteines 166 and 212.

Details

Redox score ?
91
PDB code
6ace
Structure name
histone lysine desuccinylase sirt5 in complex with succinyl peptide h3k122
Structure deposition date
2018-07-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
6
% buried
0
Peptide accession
Q9NXA8
Residue number A
166
Residue number B
212
Peptide name
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Ligandability

Cysteine 166 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NAD-dependent protein deacylase sirtuin-5, mitochondrial between cysteines 166 and 207.

Details

Redox score ?
91
PDB code
3rig
Structure name
sirt5 is an nad-dependent protein lysine demalonylase and desuccinylase
Structure deposition date
2011-04-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
5
% buried
0
Peptide accession
Q9NXA8
Residue number A
166
Residue number B
207
Peptide name
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Ligandability

Cysteine 166 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NAD-dependent protein deacylase sirtuin-5, mitochondrial between cysteines 166 and 169.

Details

Redox score ?
88
PDB code
3rig
Structure name
sirt5 is an nad-dependent protein lysine demalonylase and desuccinylase
Structure deposition date
2011-04-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
0
Peptide accession
Q9NXA8
Residue number A
166
Residue number B
169
Peptide name
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Ligandability

Cysteine 166 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NAD-dependent protein deacylase sirtuin-5, mitochondrial between cysteines 207 and 212.

Details

Redox score ?
85
PDB code
3rig
Structure name
sirt5 is an nad-dependent protein lysine demalonylase and desuccinylase
Structure deposition date
2011-04-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
0
Peptide accession
Q9NXA8
Residue number A
207
Residue number B
212
Peptide name
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Ligandability

Cysteine 207 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NAD-dependent protein deacylase sirtuin-5, mitochondrial between cysteines 169 and 207.

Details

Redox score ?
82
PDB code
4f4u
Structure name
the bicyclic intermediate structure provides insights into the desuccinylation mechanism of sirt5
Structure deposition date
2012-05-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
0
Peptide accession
Q9NXA8
Residue number A
169
Residue number B
207
Peptide name
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Ligandability

Cysteine 169 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NAD-dependent protein deacylase sirtuin-5, mitochondrial between cysteines 169 and 212.

Details

Redox score ?
81
PDB code
4f4u
Structure name
the bicyclic intermediate structure provides insights into the desuccinylation mechanism of sirt5
Structure deposition date
2012-05-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
nan
Peptide accession
Q9NXA8
Residue number A
169
Residue number B
212
Peptide name
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Ligandability

Cysteine 169 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NAD-dependent protein deacylase sirtuin-5, mitochondrial between cysteines 242 and 245.

Details

Redox score ?
64
PDB code
6ljk
Structure name
crystal structure of human sirt5 in complex with an internally quenched fluorescent substrate gluiqf
Structure deposition date
2019-12-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
86
Peptide accession
Q9NXA8
Residue number A
242
Residue number B
245
Peptide name
NAD-dependent protein deacylase sirtuin-5, mitochondrial

Ligandability

Cysteine 242 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of NAD-dependent protein deacylase sirtuin-5, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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