ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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THUMP domain-containing protein 1

Intramolecular
Cysteine 248 and cysteine 249
A redox-regulated disulphide may form within THUMP domain-containing protein 1 between cysteines 248 and 249 (86 and 87 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
2dir
Structure name
solution structure of the thump domain of thump domain-containing protein 1
Structure deposition date
2006-03-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
22
Peptide accession
Q9NXG2
Residue number A
248
Residue number B
249
Peptide name
THUMP domain-containing protein 1

Ligandability

Cysteine 248 of THUMP domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 249 of THUMP domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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