ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Transmembrane prolyl 4-hydroxylase

Intramolecular
Cysteine 340 and cysteine 357
Cysteine 404 and cysteine 444
A redox-regulated disulphide may form within Transmembrane prolyl 4-hydroxylase between cysteines 340 and 357.

Details

Redox score ?
84
PDB code
6tp5
Structure name
crystal structure of human transmembrane prolyl 4-hydroxylase
Structure deposition date
2019-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NXG6
Residue number A
340
Residue number B
357
Peptide name
Transmembrane prolyl 4-hydroxylase

Ligandability

Cysteine 340 of Transmembrane prolyl 4-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Transmembrane prolyl 4-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transmembrane prolyl 4-hydroxylase between cysteines 404 and 444.

Details

Redox score ?
83
PDB code
6tp5
Structure name
crystal structure of human transmembrane prolyl 4-hydroxylase
Structure deposition date
2019-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NXG6
Residue number A
404
Residue number B
444
Peptide name
Transmembrane prolyl 4-hydroxylase

Ligandability

Cysteine 404 of Transmembrane prolyl 4-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 444 of Transmembrane prolyl 4-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: