ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ganglioside-induced differentiation-associated protein 2

Intramolecular
Cysteine 107 and cysteine 148
Cysteine 148 and cysteine 167
A redox-regulated disulphide may form within Ganglioside-induced differentiation-associated protein 2 between cysteines 107 and 148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4uml
Structure name
crystal structure of ganglioside induced differentiation associated protein 2 (gdap2) macro domain
Structure deposition date
2014-05-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
76
Peptide accession
Q9NXN4
Residue number A
107
Residue number B
148
Peptide name
Ganglioside-induced differentiation-associated protein 2

Ligandability

Cysteine 107 of Ganglioside-induced differentiation-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Ganglioside-induced differentiation-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ganglioside-induced differentiation-associated protein 2 between cysteines 148 and 167. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4uml
Structure name
crystal structure of ganglioside induced differentiation associated protein 2 (gdap2) macro domain
Structure deposition date
2014-05-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
96
Peptide accession
Q9NXN4
Residue number A
148
Residue number B
167
Peptide name
Ganglioside-induced differentiation-associated protein 2

Ligandability

Cysteine 148 of Ganglioside-induced differentiation-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of Ganglioside-induced differentiation-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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