ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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BRISC and BRCA1-A complex member 2

Intermolecular
Cysteine 307 and cysteine 298 of BRISC and BRCA1-A complex member 1
Intramolecular
Cysteine 44 and cysteine 53
A redox-regulated disulphide may form between cysteine 307 of BRISC and BRCA1-A complex member 2 and cysteine 298 of BRISC and BRCA1-A complex member 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6gvw
Structure name
crystal structure of the brca1-a complex
Structure deposition date
2018-06-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
95
Peptide A name
BRISC and BRCA1-A complex member 2
Peptide B name
BRISC and BRCA1-A complex member 1
Peptide A accession
Q8K3W0
Peptide B accession
Q3UI43
Peptide A residue number
307
Peptide B residue number
298

Ligandability

Cysteine 307 of BRISC and BRCA1-A complex member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of BRISC and BRCA1-A complex member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within BRISC and BRCA1-A complex member 2 between cysteines 44 and 53. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6r8f
Structure name
cryo-em structure of the human brisc-shmt2 complex
Structure deposition date
2019-04-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
56
Peptide accession
Q9NXR7
Residue number A
44
Residue number B
53
Peptide name
BRISC and BRCA1-A complex member 2

Ligandability

Cysteine 44 of BRISC and BRCA1-A complex member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of BRISC and BRCA1-A complex member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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