ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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BTB/POZ domain-containing protein KCTD5

Intramolecular
Cysteine 63 and cysteine 74
Cysteine 163 and cysteine 203
A redox-regulated disulphide may form within BTB/POZ domain-containing protein KCTD5 between cysteines 63 and 74.

Details

Redox score ?
85
PDB code
3drx
Structure name
x-ray crystal structure of human kctd5 protein crystallized in high- salt buffer
Structure deposition date
2008-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NXV2
Residue number A
63
Residue number B
74
Peptide name
BTB/POZ domain-containing protein KCTD5

Ligandability

Cysteine 63 of BTB/POZ domain-containing protein KCTD5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of BTB/POZ domain-containing protein KCTD5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within BTB/POZ domain-containing protein KCTD5 between cysteines 163 and 203. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
3drx
Structure name
x-ray crystal structure of human kctd5 protein crystallized in high- salt buffer
Structure deposition date
2008-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
55
Peptide accession
Q9NXV2
Residue number A
163
Residue number B
203
Peptide name
BTB/POZ domain-containing protein KCTD5

Ligandability

Cysteine 163 of BTB/POZ domain-containing protein KCTD5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of BTB/POZ domain-containing protein KCTD5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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