ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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H/ACA ribonucleoprotein complex subunit 1

Intramolecular
Cysteine 86 and cysteine 88 L
A redox-regulated disulphide may form within H/ACA ribonucleoprotein complex subunit 1 between cysteines 86 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7v9a
Structure name
biogenesis module of human telomerase holoenzyme
Structure deposition date
2021-08-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
82
Peptide accession
Q9NY12
Residue number A
86
Residue number B
88
Peptide name
H/ACA ribonucleoprotein complex subunit 1

Ligandability

Cysteine 86 of H/ACA ribonucleoprotein complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of H/ACA ribonucleoprotein complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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