ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium channel subunit beta-3

Intermolecular
Cysteine 927 of Sodium channel protein type 7 subunit alpha and cysteine 180
Intramolecular
Cysteine 26 and cysteine 48
Cysteine 45 and cysteine 120
A redox-regulated disulphide may form between cysteine 927 of Sodium channel protein type 7 subunit alpha and cysteine 180 of Sodium channel subunit beta-3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
18
Peptide A name
Sodium channel protein type 7 subunit alpha
Peptide B name
Sodium channel subunit beta-3
Peptide A accession
Q01118
Peptide B accession
Q9NY72
Peptide A residue number
927
Peptide B residue number
180

Ligandability

Cysteine 927 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Sodium channel subunit beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel subunit beta-3 between cysteines 26 and 48.

Details

Redox score ?
73
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
58
Peptide accession
Q9NY72
Residue number A
26
Residue number B
48
Peptide name
Sodium channel subunit beta-3

Ligandability

Cysteine 26 of Sodium channel subunit beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of Sodium channel subunit beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel subunit beta-3 between cysteines 45 and 120.

Details

Redox score ?
72
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
87
Peptide accession
Q9NY72
Residue number A
45
Residue number B
120
Peptide name
Sodium channel subunit beta-3

Ligandability

Cysteine 45 of Sodium channel subunit beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Sodium channel subunit beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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