ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sulfhydryl oxidase

Intramolecular
Cysteine 170 and cysteine 187
Cysteine 141 and cysteine 144
A redox-regulated disulphide may form within Sulfhydryl oxidase between cysteines 170 and 187 (95 and 112 respectively in this structure).

Details

Redox score ?
86
PDB code
3o55
Structure name
crystal structure of human fad-linked augmenter of liver regeneration (alr)
Structure deposition date
2010-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NY86
Residue number A
170
Residue number B
187
Peptide name
Sulfhydryl oxidase

Ligandability

Cysteine 170 of Sulfhydryl oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Sulfhydryl oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase between cysteines 141 and 144 (66 and 69 respectively in this structure).

Details

Redox score ?
84
PDB code
3o55
Structure name
crystal structure of human fad-linked augmenter of liver regeneration (alr)
Structure deposition date
2010-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NY86
Residue number A
141
Residue number B
144
Peptide name
Sulfhydryl oxidase

Ligandability

Cysteine 141 of Sulfhydryl oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Sulfhydryl oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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