Toll-like receptor 7
Intramolecular
Cysteine 263 and cysteine 270
Cysteine 98 and cysteine 475
Cysteine 491 and cysteine 521
Cysteine 100 and cysteine 112
Cysteine 183 and cysteine 189
Cysteine 36 and cysteine 51
Cysteine 789 and cysteine 833
Cysteine 787 and cysteine 814
Cysteine 260 and cysteine 273
Cysteine 98 and cysteine 100
7cyn B 263 B 270
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 263 and 270.
Details
Redox score ?
86
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
263
Residue number B
270
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 263 of Toll-like receptor 7
Cysteine 270 of Toll-like receptor 7
7cyn B 98 B 475
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 98 and 475.
Details
Redox score ?
86
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
98
Residue number B
475
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 98 of Toll-like receptor 7
Cysteine 475 of Toll-like receptor 7
7cyn B 491 B 521
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 491 and 521.
Details
Redox score ?
86
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
491
Residue number B
521
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 491 of Toll-like receptor 7
Cysteine 521 of Toll-like receptor 7
7cyn A 100 A 112
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 100 and 112.
Details
Redox score ?
84
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
100
Residue number B
112
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 100 of Toll-like receptor 7
Cysteine 112 of Toll-like receptor 7
7cyn B 183 B 189
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 183 and 189.
Details
Redox score ?
83
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
183
Residue number B
189
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 183 of Toll-like receptor 7
Cysteine 189 of Toll-like receptor 7
7cyn B 36 B 51
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 36 and 51.
Details
Redox score ?
83
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
36
Residue number B
51
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 36 of Toll-like receptor 7
Cysteine 51 of Toll-like receptor 7
7cyn A 789 A 833
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 789 and 833.
Details
Redox score ?
81
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
789
Residue number B
833
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 789 of Toll-like receptor 7
Cysteine 833 of Toll-like receptor 7
7cyn B 787 B 814
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 787 and 814.
Details
Redox score ?
81
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
787
Residue number B
814
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 787 of Toll-like receptor 7
Cysteine 814 of Toll-like receptor 7
7cyn B 260 B 273
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 260 and 273.
Details
Redox score ?
77
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
30
Peptide accession
Q9NYK1
Residue number A
260
Residue number B
273
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 260 of Toll-like receptor 7
Cysteine 273 of Toll-like receptor 7
7cyn B 98 B 100
A redox-regulated disulphide may form within Toll-like receptor 7 between cysteines 98 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7cyn
Structure name
cryo-em structure of human tlr7 in complex with unc93b1
Structure deposition date
2020-09-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NYK1
Residue number A
98
Residue number B
100
Peptide name
Toll-like receptor 7
Ligandability
Cysteine 98 of Toll-like receptor 7
Cysteine 100 of Toll-like receptor 7
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