ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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39S ribosomal protein L39, mitochondrial

Intramolecular
Cysteine 146 and cysteine 275
Cysteine 91 and cysteine 123
Cysteine 91 and cysteine 100
A redox-regulated disulphide may form within 39S ribosomal protein L39, mitochondrial between cysteines 146 and 275.

Details

Redox score ?
67
PDB code
3j7y
Structure name
structure of the large ribosomal subunit from human mitochondria
Structure deposition date
2014-08-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
100
Peptide accession
Q9NYK5
Residue number A
146
Residue number B
275
Peptide name
39S ribosomal protein L39, mitochondrial

Ligandability

Cysteine 146 of 39S ribosomal protein L39, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of 39S ribosomal protein L39, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein L39, mitochondrial between cysteines 91 and 123. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5oom
Structure name
structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rrna
Structure deposition date
2017-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
76
Peptide accession
Q9NYK5
Residue number A
91
Residue number B
123
Peptide name
39S ribosomal protein L39, mitochondrial

Ligandability

Cysteine 91 of 39S ribosomal protein L39, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of 39S ribosomal protein L39, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein L39, mitochondrial between cysteines 91 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7oi8
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 3a
Structure deposition date
2021-05-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
89
Peptide accession
Q9NYK5
Residue number A
91
Residue number B
100
Peptide name
39S ribosomal protein L39, mitochondrial

Ligandability

Cysteine 91 of 39S ribosomal protein L39, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of 39S ribosomal protein L39, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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