ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RNA polymerase I-specific transcription initiation factor RRN3

Intramolecular
Cysteine 460 and cysteine 505
A redox-regulated disulphide may form within RNA polymerase I-specific transcription initiation factor RRN3 between cysteines 460 and 505. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7oba
Structure name
cryo-em structure of human rna polymerase i in complex with rrn3
Structure deposition date
2021-04-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
84
Peptide accession
Q9NYV6
Residue number A
460
Residue number B
505
Peptide name
RNA polymerase I-specific transcription initiation factor RRN3

Ligandability

Cysteine 460 of RNA polymerase I-specific transcription initiation factor RRN3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 505 of RNA polymerase I-specific transcription initiation factor RRN3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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