ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein kinase PLK2

Intramolecular
Cysteine 347 and cysteine 348
Cysteine 491 and cysteine 665
Cysteine 482 and cysteine 665
A redox-regulated disulphide may form within Serine/threonine-protein kinase PLK2 between cysteines 347 and 348. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4i6b
Structure name
selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce -synuclein phosphorylation in rat brain
Structure deposition date
2012-11-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
40
Peptide accession
Q9NYY3
Residue number A
347
Residue number B
348
Peptide name
Serine/threonine-protein kinase PLK2

Ligandability

Cysteine 347 of Serine/threonine-protein kinase PLK2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 348 of Serine/threonine-protein kinase PLK2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase PLK2 between cysteines 491 and 665. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4xb0
Structure name
structure of the plk2 polo-box domain
Structure deposition date
2014-12-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
26
Peptide accession
Q9NYY3
Residue number A
491
Residue number B
665
Peptide name
Serine/threonine-protein kinase PLK2

Ligandability

Cysteine 491 of Serine/threonine-protein kinase PLK2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 665 of Serine/threonine-protein kinase PLK2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase PLK2 between cysteines 482 and 665. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4xb0
Structure name
structure of the plk2 polo-box domain
Structure deposition date
2014-12-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
57
Peptide accession
Q9NYY3
Residue number A
482
Residue number B
665
Peptide name
Serine/threonine-protein kinase PLK2

Ligandability

Cysteine 482 of Serine/threonine-protein kinase PLK2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 665 of Serine/threonine-protein kinase PLK2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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