ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Endoplasmic reticulum aminopeptidase 1

Intramolecular
Cysteine 404 and cysteine 443
Cysteine 736 and cysteine 743
A redox-regulated disulphide may form within Endoplasmic reticulum aminopeptidase 1 between cysteines 404 and 443.

Details

Redox score ?
80
PDB code
3mdj
Structure name
er aminopeptidase, erap1, bound to the zinc aminopeptidase inhibitor, bestatin
Structure deposition date
2010-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZ08
Residue number A
404
Residue number B
443
Peptide name
Endoplasmic reticulum aminopeptidase 1

Ligandability

Cysteine 404 of Endoplasmic reticulum aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 443 of Endoplasmic reticulum aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endoplasmic reticulum aminopeptidase 1 between cysteines 736 and 743.

Details

Redox score ?
70
PDB code
6mgq
Structure name
erap1 in the open conformation bound to 10mer phosphinic inhibitor dg014
Structure deposition date
2018-09-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZ08
Residue number A
736
Residue number B
743
Peptide name
Endoplasmic reticulum aminopeptidase 1

Ligandability

Cysteine 736 of Endoplasmic reticulum aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 743 of Endoplasmic reticulum aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: