ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Actin-related protein 10

Intramolecular
Cysteine 160 and cysteine 291
Cysteine 27 and cysteine 37 L
A redox-regulated disulphide may form within Actin-related protein 10 between cysteines 160 and 291.

Details

Redox score ?
74
PDB code
5afu
Structure name
cryo-em structure of dynein tail-dynactin-bicd2n complex
Structure deposition date
2015-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
100
Peptide accession
I3LHK5
Residue number A
160
Residue number B
291
Peptide name
Actin-related protein 10

Ligandability

Cysteine 160 of Actin-related protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of Actin-related protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 10 between cysteines 27 and 37. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6f1t
Structure name
cryo-em structure of two dynein tail domains bound to dynactin and bicdr1
Structure deposition date
2017-11-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
80
Peptide accession
I3LHK5
Residue number A
27
Residue number B
37
Peptide name
Actin-related protein 10

Ligandability

Cysteine 27 of Actin-related protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Actin-related protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: