ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neuroligin-3

Intramolecular
Cysteine 487 and cysteine 521
Cysteine 317 and cysteine 328
Cysteine 103 and cysteine 138
A redox-regulated disulphide may form within Neuroligin-3 between cysteines 487 and 521.

Details

Redox score ?
85
PDB code
7ceg
Structure name
crystal structure of the complex between mouse ptp delta and neuroligin-3
Structure deposition date
2020-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BYM5
Residue number A
487
Residue number B
521
Peptide name
Neuroligin-3

Ligandability

Cysteine 487 of Neuroligin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 521 of Neuroligin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroligin-3 between cysteines 317 and 328.

Details

Redox score ?
83
PDB code
7ceg
Structure name
crystal structure of the complex between mouse ptp delta and neuroligin-3
Structure deposition date
2020-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BYM5
Residue number A
317
Residue number B
328
Peptide name
Neuroligin-3

Ligandability

Cysteine 317 of Neuroligin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Neuroligin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroligin-3 between cysteines 103 and 138.

Details

Redox score ?
81
PDB code
7cee
Structure name
crystal structure of mouse neuroligin-3
Structure deposition date
2020-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BYM5
Residue number A
103
Residue number B
138
Peptide name
Neuroligin-3

Ligandability

Cysteine 103 of Neuroligin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Neuroligin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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