Triggering receptor expressed on myeloid cells 2
Intramolecular
Cysteine 51 and cysteine 60
Cysteine 36 and cysteine 110
Cysteine 60 and cysteine 110
Cysteine 51 and cysteine 110
6b8o D 51 D 60
A redox-regulated disulphide may form within Triggering receptor expressed on myeloid cells 2 between cysteines 51 and 60.
Details
Redox score ?
82
PDB code
6b8o
Structure name
wt ig-like v domain with phosphatidylserine
Structure deposition date
2017-10-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
34
Peptide accession
Q9NZC2
Residue number A
51
Residue number B
60
Peptide name
Triggering receptor expressed on myeloid cells 2
Ligandability
Cysteine 51 of Triggering receptor expressed on myeloid cells 2
Cysteine 60 of Triggering receptor expressed on myeloid cells 2
5ud8 B 36 B 110
A redox-regulated disulphide may form within Triggering receptor expressed on myeloid cells 2 between cysteines 36 and 110.
Details
Redox score ?
80
PDB code
5ud8
Structure name
crystal structure of mutant ig-like domain
Structure deposition date
2016-12-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZC2
Residue number A
36
Residue number B
110
Peptide name
Triggering receptor expressed on myeloid cells 2
Ligandability
Cysteine 36 of Triggering receptor expressed on myeloid cells 2
Cysteine 110 of Triggering receptor expressed on myeloid cells 2
6b8o C 60 C 110
A redox-regulated disulphide may form within Triggering receptor expressed on myeloid cells 2 between cysteines 60 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6b8o
Structure name
wt ig-like v domain with phosphatidylserine
Structure deposition date
2017-10-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9NZC2
Residue number A
60
Residue number B
110
Peptide name
Triggering receptor expressed on myeloid cells 2
Ligandability
Cysteine 60 of Triggering receptor expressed on myeloid cells 2
Cysteine 110 of Triggering receptor expressed on myeloid cells 2
6xds A 401 A 460
A redox-regulated disulphide may form within Triggering receptor expressed on myeloid cells 2 between cysteines 51 and 110 (401 and 460 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6xds
Structure name
crystal structure of mbp-trem2 ig domain fusion with fragment, 2-((4- bromophenyl)amino)ethan-1-ol
Structure deposition date
2020-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZC2
Residue number A
51
Residue number B
110
Peptide name
Triggering receptor expressed on myeloid cells 2
Ligandability
Cysteine 51 of Triggering receptor expressed on myeloid cells 2
Cysteine 110 of Triggering receptor expressed on myeloid cells 2
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