ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-37

Intramolecular
Cysteine 181 and cysteine 183
Cysteine 178 and cysteine 181
A redox-regulated disulphide may form within Interleukin-37 between cysteines 181 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5hn1
Structure name
crystal structure of interleukin-37
Structure deposition date
2016-01-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
6
Peptide accession
Q9NZH6
Residue number A
181
Residue number B
183
Peptide name
Interleukin-37

Ligandability

Cysteine 181 of Interleukin-37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Interleukin-37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-37 between cysteines 178 and 181. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5hn1
Structure name
crystal structure of interleukin-37
Structure deposition date
2016-01-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
26
Peptide accession
Q9NZH6
Residue number A
178
Residue number B
181
Peptide name
Interleukin-37

Ligandability

Cysteine 178 of Interleukin-37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Interleukin-37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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