a tool for identifying drug-targetable redox-active disulphides

Eukaryotic translation initiation factor 2-alpha kinase 3

Intramolecular

Cysteine 216 and cysteine 221

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2-alpha kinase 3 between cysteines 216 and 221.

Details

Redox score ?

69

PDB code

Structure name

the crystal structure of a chaperone

Structure deposition date

2016-08-04

Thiol separation (Å)

5

Half-sphere exposure sum ?

67

Minimum pK_a ?

10

% buried

39

Peptide accession

Residue number A

216

Residue number B

221

Peptide name

Eukaryotic translation initiation factor 2-alpha kinase 3

Ligandability

Cysteine 216 of Eukaryotic translation initiation factor 2-alpha kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Eukaryotic translation initiation factor 2-alpha kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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