ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Diphosphoinositol polyphosphate phosphohydrolase 2

Intermolecular
Cysteine 130 and cysteine 130
Intramolecular
Cysteine 23 and cysteine 25
A redox-regulated disulphide may form between two units of Diphosphoinositol polyphosphate phosphohydrolase 2 at cysteines 130 and 130 (123 and 123 respectively in this structure).

Details

Redox score ?
83
PDB code
2duk
Structure name
crystal structure of ms0616
Structure deposition date
2006-07-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide A name
Diphosphoinositol polyphosphate phosphohydrolase 2
Peptide B name
Diphosphoinositol polyphosphate phosphohydrolase 2
Peptide A accession
Q8R2U6
Peptide B accession
Q8R2U6
Peptide A residue number
130
Peptide B residue number
130

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Diphosphoinositol polyphosphate phosphohydrolase 2 between cysteines 23 and 25.

Details

Redox score ?
62
PDB code
7nnj
Structure name
crystal structure of nudt4 (diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-o-bn-1-pcp-insp4 (amr2105)
Structure deposition date
2021-02-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
105
Minimum pKa ?
9
% buried
100
Peptide accession
Q9NZJ9
Residue number A
23
Residue number B
25
Peptide name
Diphosphoinositol polyphosphate phosphohydrolase 2

Ligandability

Cysteine 23 of Diphosphoinositol polyphosphate phosphohydrolase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Diphosphoinositol polyphosphate phosphohydrolase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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