a tool for identifying drug-targetable redox-active disulphides

Adenosine deaminase 2

Intramolecular

Cysteine 137 and cysteine 159

A redox-regulated disulphide may form within Adenosine deaminase 2 between cysteines 137 and 159 (111 and 133 respectively in this structure).

Details

Redox score ?

86

PDB code

Structure name

crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin

Structure deposition date

2010-01-20

Thiol separation (Å)

2

Half-sphere exposure sum ?

56

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

137

Residue number B

159

Peptide name

Adenosine deaminase 2

Ligandability

Cysteine 137 of Adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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