Group IIE secretory phospholipase A2
Intramolecular
Cysteine 77 and cysteine 101
Cysteine 67 and cysteine 142
Cysteine 44 and cysteine 135
Cysteine 46 and cysteine 62
Cysteine 95 and cysteine 106
Cysteine 68 and cysteine 108
Cysteine 61 and cysteine 115
Cysteine 61 and cysteine 62
Cysteine 46 and cysteine 61
Cysteine 77 and cysteine 108
More...Cysteine 62 and cysteine 115
Cysteine 68 and cysteine 142
Cysteine 46 and cysteine 115
Cysteine 67 and cysteine 68
Cysteine 95 and cysteine 108
Cysteine 44 and cysteine 46
Cysteine 106 and cysteine 108
Cysteine 67 and cysteine 108
5wzt A 58 A 82
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 77 and 101 (58 and 82 respectively in this structure).
Details
Redox score ?
86
PDB code
5wzt
Structure name
crystal structure of human secreted phospholipase a2 group iie with compound 14
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
77
Residue number B
101
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 77 of Group IIE secretory phospholipase A2
Cysteine 101 of Group IIE secretory phospholipase A2
5wzu A 48 A 123
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 67 and 142 (48 and 123 respectively in this structure).
Details
Redox score ?
86
PDB code
5wzu
Structure name
crystal structure of human secreted phospholipase a2 group iie with compound 24
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
67
Residue number B
142
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 67 of Group IIE secretory phospholipase A2
Cysteine 142 of Group IIE secretory phospholipase A2
5wzv A 25 A 116
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 44 and 135 (25 and 116 respectively in this structure).
Details
Redox score ?
84
PDB code
5wzv
Structure name
crystal structure of human secreted phospholipase a2 group iie with me-indoxam
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
44
Residue number B
135
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 44 of Group IIE secretory phospholipase A2
Cysteine 135 of Group IIE secretory phospholipase A2
5wzo A 27 A 43
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 46 and 62 (27 and 43 respectively in this structure).
Details
Redox score ?
83
PDB code
5wzo
Structure name
crystal structure of human secreted phospholipase a2 group iie, crystallized with calcium
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
46
Residue number B
62
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 46 of Group IIE secretory phospholipase A2
Cysteine 62 of Group IIE secretory phospholipase A2
5wzu A 76 A 87
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 95 and 106 (76 and 87 respectively in this structure).
Details
Redox score ?
83
PDB code
5wzu
Structure name
crystal structure of human secreted phospholipase a2 group iie with compound 24
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
95
Residue number B
106
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 95 of Group IIE secretory phospholipase A2
Cysteine 106 of Group IIE secretory phospholipase A2
5wzt A 49 A 89
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 68 and 108 (49 and 89 respectively in this structure).
Details
Redox score ?
81
PDB code
5wzt
Structure name
crystal structure of human secreted phospholipase a2 group iie with compound 14
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
68
Residue number B
108
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 68 of Group IIE secretory phospholipase A2
Cysteine 108 of Group IIE secretory phospholipase A2
5wzw A 42 A 96
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 61 and 115 (42 and 96 respectively in this structure).
Details
Redox score ?
80
PDB code
5wzw
Structure name
crystal structure of human secreted phospholipase a2 group iie with ly311727
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
61
Residue number B
115
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 61 of Group IIE secretory phospholipase A2
Cysteine 115 of Group IIE secretory phospholipase A2
5wzw A 42 A 43
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 61 and 62 (42 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
5wzw
Structure name
crystal structure of human secreted phospholipase a2 group iie with ly311727
Structure deposition date
2017-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
61
Residue number B
62
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 61 of Group IIE secretory phospholipase A2
Cysteine 62 of Group IIE secretory phospholipase A2
6kqu A 27 A 42
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 46 and 61 (27 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6kqu
Structure name
crystal structure of phospholipase a2
Structure deposition date
2019-08-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
46
Residue number B
61
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 46 of Group IIE secretory phospholipase A2
Cysteine 61 of Group IIE secretory phospholipase A2
5wzv A 58 A 89
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 77 and 108 (58 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5wzv
Structure name
crystal structure of human secreted phospholipase a2 group iie with me-indoxam
Structure deposition date
2017-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
77
Residue number B
108
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 77 of Group IIE secretory phospholipase A2
Cysteine 108 of Group IIE secretory phospholipase A2
5wzm A 43 A 96
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 62 and 115 (43 and 96 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5wzm
Structure name
crystal structure of human secreted phospholipase a2 group iie
Structure deposition date
2017-01-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
62
Residue number B
115
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 62 of Group IIE secretory phospholipase A2
Cysteine 115 of Group IIE secretory phospholipase A2
5wzu A 49 A 123
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 68 and 142 (49 and 123 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5wzu
Structure name
crystal structure of human secreted phospholipase a2 group iie with compound 24
Structure deposition date
2017-01-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
68
Residue number B
142
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 68 of Group IIE secretory phospholipase A2
Cysteine 142 of Group IIE secretory phospholipase A2
5wzv A 27 A 96
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 46 and 115 (27 and 96 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
5wzv
Structure name
crystal structure of human secreted phospholipase a2 group iie with me-indoxam
Structure deposition date
2017-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
46
Residue number B
115
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 46 of Group IIE secretory phospholipase A2
Cysteine 115 of Group IIE secretory phospholipase A2
5wzm A 48 A 49
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 67 and 68 (48 and 49 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5wzm
Structure name
crystal structure of human secreted phospholipase a2 group iie
Structure deposition date
2017-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
67
Residue number B
68
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 67 of Group IIE secretory phospholipase A2
Cysteine 68 of Group IIE secretory phospholipase A2
5wzw A 76 A 89
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 95 and 108 (76 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
5wzw
Structure name
crystal structure of human secreted phospholipase a2 group iie with ly311727
Structure deposition date
2017-01-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
95
Residue number B
108
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 95 of Group IIE secretory phospholipase A2
Cysteine 108 of Group IIE secretory phospholipase A2
6kqu A 25 A 27
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 44 and 46 (25 and 27 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6kqu
Structure name
crystal structure of phospholipase a2
Structure deposition date
2019-08-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
44
Residue number B
46
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 44 of Group IIE secretory phospholipase A2
Cysteine 46 of Group IIE secretory phospholipase A2
5wzo A 87 A 89
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 106 and 108 (87 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
5wzo
Structure name
crystal structure of human secreted phospholipase a2 group iie, crystallized with calcium
Structure deposition date
2017-01-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
106
Residue number B
108
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 106 of Group IIE secretory phospholipase A2
Cysteine 108 of Group IIE secretory phospholipase A2
6kqu A 48 A 89
A redox-regulated disulphide may form within Group IIE secretory phospholipase A2 between cysteines 67 and 108 (48 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6kqu
Structure name
crystal structure of phospholipase a2
Structure deposition date
2019-08-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NZK7
Residue number A
67
Residue number B
108
Peptide name
Group IIE secretory phospholipase A2
Ligandability
Cysteine 67 of Group IIE secretory phospholipase A2
Cysteine 108 of Group IIE secretory phospholipase A2
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