ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Methionine adenosyltransferase 2 subunit beta

Intramolecular
Cysteine 93 and cysteine 231
Cysteine 58 and cysteine 93
A redox-regulated disulphide may form within Methionine adenosyltransferase 2 subunit beta between cysteines 93 and 231 (82 and 220 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4ktv
Structure name
structural insights of mat enzymes: mata2b complexed with adenosine and pyrophosphate
Structure deposition date
2013-05-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NZL9
Residue number A
93
Residue number B
231
Peptide name
Methionine adenosyltransferase 2 subunit beta

Ligandability

Cysteine 93 of Methionine adenosyltransferase 2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 231 of Methionine adenosyltransferase 2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine adenosyltransferase 2 subunit beta between cysteines 58 and 93 (47 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
4ndn
Structure name
structural insights of mat enzymes: mata2b complexed with sam and ppnp
Structure deposition date
2013-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
96
Peptide accession
Q9NZL9
Residue number A
58
Residue number B
93
Peptide name
Methionine adenosyltransferase 2 subunit beta

Ligandability

Cysteine 58 of Methionine adenosyltransferase 2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Methionine adenosyltransferase 2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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